Introduction

Cells in the immune system are tuned exquisitely to avoid the extremes of immunodeficiency and autoimmunity. We apply the tools of biochemistry, immunology, biophysics, and structural biology to understand macrophage and lymphocyte signaling with the goal of understanding how inflammation and dysregulation can affect cell sensitivity and exacerbate disease, how protein-protein interactions at the plasma membrane regulate signaling, and how receptor clustering enables signaling.

Click on each project above to learn more! Key publications that reflect some of our current interests (and a few favorites from the past) are flagged { KEY PAPER }. Of course, we also have interests and projects in progress that aren't yet reflected in our publication record.

News @tfreedmanlab

  • November, 2020
    MSTP student Anders Linstedt will be joining the lab in the spring! If you run into him before then, be sure to give him a warm welcome!

    November, 2020
    Please join us in welcoming rotation student Jennifer Tuokkola from the Pharmacology Graduate Program! We'll all be working together to make this a productive & safe rotation experience!

    November, 2020
    Please join us in welcoming Researcher Luis Ramirez to the lab!

    October, 2020
    Please join us in welcoming rotation student Korbyn Dahlquist from BMBB! We'll all be working together to make this a productive & safe rotation experience!

    September, 2020
    PhD student Ben Brian's recent protocol/review article, "Immunopharmacology and quantitative analysis of tyrosine kinase signaling," is now out in Current Protocols in Immunology! Nice work, Ben!

    September, 2020
    Please join us in welcoming rotation students Anna Carey from Pharmacology and Evan Kleinboehl from BMBB! We'll all be working together to make this a productive & safe rotation experience!

    August, 2020
    Congratulations to lab alumna Frankie Sjaastad for a successful PhD thesis defense! Frankie was our first researcher, helping to set up the lab and recruiting our first PhD student before joining UMN's MICaB program. Best of luck in your postdoc, Dr. Sjaastad!

    August, 2020
    Welcome, first-year PhD students! We are seeking rotation students and invite you to reach out to Tanya and members of the lab. Check out our intro video.

    Our lab has broad interests in basic and biomedical research encompassing cell signaling, immunology, cancer biology, and structure-function, using methods ranging from purified proteins to mouse models and human samples. An immunology background is not a prerequisite. (Motivation to gain the expertise you need for success is!)

    August, 2020
    PhD student Ben Brian's manuscript reviewing methods for quantifying tyrosine kinase signaling has been accepted for publication in Current Protocols in Immunology. Nice work, Ben!!

    July, 2020
    Check out our perspective piece, now out in the Journal of Experimental Medicine (J Exp Med): Lessons of COVID-19: A roadmap for post-pandemic science.

    June, 2020
    PhD student Ben Brian just submitted an invited methodology review on quantitative analysis of tyrosine kinase signaling in immune cells. Stay tuned for updates!

    May, 2020
    Please join us in congratulating postdoc J.T. Greene for winning the Pharmacology Department Frederick E. Shideman Research Proposal Award in recognition of "exciting new research projects and persuasive scientific writing."

    Hearty congratulations also to PhD student Ben Brian, recipient of a Pharmacology Department Research-Leadership Publication Award, recognizing trainees or staff who "drive the science and/or writing of a publication to an extraordinary extent."

    April, 2020
    Quite a day for PhD student Ben Brian! He just won two more awards from the UMN Medical school.
    - The J. Jacob Kaplan Award for clinical or basic research in immunology in diagnosis and treatment of cancer, in gastroenterology, or in cardiology
    - The Veneziale-Steer Award for outstanding basic scientific research by a graduate student or a medical student in the field of cellular growth regulation.

    April, 2020
    A welcome bit of good news: congratulations to postdoc J.T. Greene for securing funding via the Cancer Biology Training Grant, administered through the UMN Masonic Cancer Center and funded by the National Cancer Institute within the NIH.

    April, 2020
    We are looking forward to working with three undergraduate students this summer, with remote mentorship and (hopefully!) bench research.

    Our current undergraduate Freya van't Veer will come work with us full time-- she has some interesting observations about hormone signaling in macrophages, and we're excited for her to continue her project!

    We are also excited to welcome Zach Kulstad from Carleton College and Emmanuel León-Colón, an LSSURP student from Universidad de Puerto Rico, Ponce. The on-campus program was unfortunately suspended this year, but we're looking forward to getting to know Emmanuel remotely and introducing him to the research environment at UMN!

    March, 2020
    As part of a University-wide commitment to social distancing and to do our part to keep our people safe and slow down the influx of new patients in a medical system stretched to its limits worldwide, We have moved to minimal in-lab operations.

    If we work together we can FLATTEN THE CURVE.

    For information on COVID-19 and the novel coronavirus, please choose your sources carefully. We recommend visiting NIAID and the WHO for information about current public safety recommendations and the latest research efforts.

    March, 2020
    We are now affiliated with three graduate programs at the University of Minnesota: Pharmacology, MICaB (Microbiology/Immunology/Cancer Biology), and BMBB (Biochemistry/Molecular Biology/Biophysics)!

    February, 2020
    Pharmacology PhD student Erandika Senevirathne has joined the lab! Please join us giving her a warm welcome.

    January, 2020
    Congratulations to PhD student Ben Brian, winner of the prestigious Dr. Marvin and Hadassah Bacaner Research Award in Pharmacology! So well deserved!

    January, 2020
    Happy new year! Please join us in welcoming two Pharmacology rotation students, Erandika Senevirathne and Mark Schonfeld, who are tackling big questions in macrophage negative-feedback and Csk regulation. We'll be grateful for their efforts during our upcoming recruitment weekend. Our students are powerful emissaries for our graduate programs!

    December, 2019
    It's been a big year for PhD student Ben Brian! He published his first paper this past summer and gave a truly excellent Pharmacology Department seminar earlier this month! Postdoc J.T. Greene and Researcher Adrienne Joliceour gave great talks of their own at the UMN/Mayo Joint Immunology Retreat and at the Autumn Immunology Conference (Chicago, IL), respectively. Looking forward to a great new year and to seeing some new faces in the lab!

    November, 2019
    Join us in welcoming MICaB rotation student Jake Hildebrand, who will take the lead analyzing Tuberculosis infection data and studying macrophage signaling! (The graduate program in Pharmacology will be represented in the new year...)

    October, 2019
    Postdoc J.T. Greene did a great job presenting his tumor data at the Mayo Clinic/University of Minnesota joint immunology retreat. Nice work, J.T.!

    August, 2019
    We are currently seeking rotation students! Contact Tanya if you're interested in talking about projects.

    July, 2019
    Our recent paper is now available in its final, formatted version at eLife! Really proud of the great effort that Ben, Adrienne, and Myra put into this.

    July, 2019
    PhD student Ben Brian's manuscript has been accepted for publication in eLife. Nice work, Ben!!

    Join us in welcoming postdoc J.T. Greene, who will study myeloid-cell signaling in the tumor microenvironment!

    MSTP student Anders Lindstedt will spend his first rotation in the lab! Join us in giving him a warm welcome. (Also, ask him about his previous research experience at the NIH!)

    May, 2019
    Join us in welcoming high-school student Cissi Schultz, who is hard at work on experiments measuring macrophage and T-cell activation!

    May, 2019
    We should not neglect funding for basic research! Check out our cancer research goals within the Masonic Cancer Center at UMN!

    April, 2019
    Hard at work on revisions for PhD student Ben Brian's mansucript resubmission...

    March, 2019
    We now have a lab Twitter account! Follow @tfreedmanlab for the latest goings-on.

    February, 2019
    PhD student Ben Brian just submitted his first paper, which includes a beautiful comparison of macrophage and mast cell signaling. Check out a preprint at bioRxiv doi:10.1101/550053.

    January, 2019
    PhD students Dechen Wangmo and Aditi Bapat are spending their third rotation with us! Looking forward to investigating signaling in human macrophages and studying how Src-family kinase signaling shapes the breast tumor microenvironment!

    2018
    Pharmacology students in our lab are eligible for Pharmacology Department Awards, which recognize stellar research proposals, scientific leadership, and publications and subsidize travel to conferences.

    Join us in welcoming researcher Adrienne Jolicoeur to the lab! Adrienne and Myra will be working together to study myeloid-cell signaling in isolated cells and in the context of autoimmune arthritis.

    Thanks to the University of Minnesota Foundation and the UMN Medical School for a Faculty Equipment Award! The requested near-infrared imager is essential for us (and our colleagues) to do quantitative research in cell signaling!

    Thanks to Dean Jakub Tolar for recognizing our research as part of the 130th Anniversary celebration for the UMN Medical School!

  • Thanks to the NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases) for funding our R01 grant (AR073966): "Roles of the Src-family kinases LynA and LynB in macrophage inflammatory signaling!"

    We are excited to begin this work and acknowledge important discussions and collaborations with colleagues Bryce Binstadt, Marc Jenkins, Kaylee Schwertfeger, and Cliff Lowell!

    PhD student Ben Brian is preparing a manuscript for publication! Stay tuned for more about LynA and E3 ubiquitin ligases!

    Please join us in welcoming Myra Nunez to the lab!
    Thanks to the UMN Center for Autoimmune Diseases Rssearch (CADRe) for a Pilot Grant to fund our first studies of human macrophages and inflammatory arthritis!

    2017
    Please join us in congratulating PhD student Ben Brian for advancing to the final round of the 3 Minute Thesis competition in the UMN Medical School

    PhD student Ben Brian gave a research talk at the UChicago/UMN Immunology Retreat on his recent discoveries about ultrafast degradation processes in Src-family kinases and a novel model for studying breast cancer!

    We are now studying the roles of Src-family kinases in autoimmune arthritis, thanks to "New Mouse Award" funding from the UMN Center for Immunology!

  • We are hard at work making new mouse models to study the unique functions of the Src-family kinases LynA and LynB! Thanks to the National Institute of Allergy and Infectious Diseases at the NIH for the funding to get this exciting project started!

  • 2016
    PhD student Ben Brian gave a terrific talk at the Autumn Immunology Conference in Chicago! Go Ben!

  • Thanks to the American Cancer Society for a UMN Masonic Cancer Center Instutional Research Grant!

  • Tanya is now a member of UMN's Microbiology, Immunology, and Cancer Biology (MICaB) Graduate Program! Since their admissions priorities vary independently from year to year, potential PhD students are strongly encouraged to apply to both MICaB and the Graduate Program in Pharmacology.

  • Whitney Swanson joins the lab!

    Please join us in congratulating our Researcher Frankie Sjaastad, who will leave the lab pursue a PhD in the MICaB Graduate Program!

  • Ben Brian, a Pharmacology PhD student, joins the lab!

  • 2015
    Thanks to the UMN Office of the Vice President for a Grant-in-Aid of Research, Artistry, and Scholarship!

  • We are happy to welcome Ben Brian, a rotation student from the Pharmacology Graduate Program!

  • Check out our new paper in eLife!
    "LynA regulates an inflammation-sensitive signaling checkpoint in macrophages"

  • Thanks to the University of Minnesota Foundation and the UMN Medical School for a UMF Faculty Research and Equipment Award!

  • Avin Persaud and Frankie (Rosie) Rossini join the lab!

  • Frankie Sjaastad joins the Freedman Lab!

  • Tanya becomes a member of the Graduate Program in Pharmacology!

  • 2014
  • Looking for a junior scientist and thinking about macrophages

  • Safety approvals pending

    Tanya moves into her office at 3-190 WMBB and her lab space at 2-200. Drop by and say “Hi”!